BAG5

Across TCGA cell cohorts, BAG5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,128 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BAG5-associated GO terms across cancer lineages are Negative regulation of protein refolding, Vesicle tethering, and Negative regulation of protein folding. Each is linked with BAG5 in more than 15 cancer types. Because this analysis shows association rather than direction, both BAG5-to-partner and partner-to-BAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein refolding grouped by BAG5-low versus BAG5-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG5→partner) and Y-score (partner→BAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of protein refolding →	+0.148	+0.596	.002	.008	3	16
BREAST	Vesicle tethering →	+0.078	+0.656	.001	.007	3	14
BLOOD_Myeloma	Negative regulation of protein folding →	+0.132	+0.941	<.001	<.001	3	14
OVARY	Positive regulation of cytoplasmic translation →	+0.096	+0.487	<.001	<.001	3	13
BREAST	Regulation of stem cell population maintenance →	+0.064	+0.768	.003	<.001	3	13
STOMACH	Vesicle tethering to Golgi →	+0.105	+0.607	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,128 associations by consensus.

Negative regulation of protein refolding by BAG5 expression — LUNG_NSCLC_LUSC

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