BAG5

Across TCGA cell cohorts, BAG5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BAG5-associated genes across cancer lineages are ETNPPL, DEFA4, and BPIFA1. Each is linked with BAG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG5-to-partner and partner-to-BAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETNPPL grouped by BAG5-low versus BAG5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG5→partner) and Y-score (partner→BAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETNPPL →	+0.224	+3.758	.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPIFA1 →	+0.134	+3.688	.001	.002	3	1
LARGE_INTESTINE	ACSM6 →	+0.019	+3.658	.002	.005	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ETNPPL by BAG5 expression — LARGE_INTESTINE

Explore this box plot interactively →