BAG4

Across TCGA pan-cancer cohorts, BAG4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated BAG4 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher BAG4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BAG4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where BAG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.946	0.414	.002	39	view →
HNSC	OS	Quartile	All	0.591	0.840	.012	16	view →
PDAC	DFS	Quartile	III,IV	0.393	0.884	.026	5	view →
GBM	DFS	Tertile	All	0.287	0.511	.043	4	view →
UCEC	OS	Quartile	All	0.858	1.000	.026	2	view →
LSCC	OS	Tertile	All	1.000	0.916	.036	2	view →
CCRCC	OS	Median	All	0.913	0.726	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

BAG4–LUAD (OS)

Open the LUAD breakdown →