BAG4

Across TCGA patient cohorts, BAG4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG4-associated genes across cancer lineages are Annexin-1, ERK2, and FOXO3a_pS318_S321. Each is linked with BAG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG4-to-partner and partner-to-BAG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by BAG4-low versus BAG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG4→partner) and Y-score (partner→BAG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.639	+2.321	.015	.035	3	2
UCEC	ERK2 →	+0.222	+2.321	.021	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.134	-3.459	.032	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.262	-3.446	.001	.005	3	1
UCEC	MEK1_p_S217_S221 →	-0.338	-3.169	.013	.019	3	1
UCEC	Rictor_pT1135 →	-0.122	-2.321	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Annexin-1 by BAG4 expression — UCEC

Explore this box plot interactively →