BAG1

Across TCGA pan-cancer cohorts, BAG1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BAG1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BAG1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BAG1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where BAG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	0.843	0.176	.008	20	view →
CCRCC	OS	Quartile	All	0.957	0.713	.004	7	view →
GBM	OS	Tertile	All	0.955	0.837	.027	3	view →
LUAD	OS	Quartile	II,III,IV	0.262	0.872	.003	2	view →
LSCC	OS	Median	All	1.000	0.813	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BAG1–PDAC (OS)

Open the PDAC breakdown →