BAG1

Across TCGA patient cohorts, BAG1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,675 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BAG1-associated genes across cancer lineages are GBA2, TOPORS, and NFX1. Each is linked with BAG1 in more than 6 cancer types. Because this analysis shows association rather than direction, both BAG1-to-partner and partner-to-BAG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BAG1 versus GBA2 in LSCC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG1→partner) and Y-score (partner→BAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GBA2 →	+0.692	+0.374	<.001	<.001	3	7
LSCC	TOPORS →	+0.590	+0.319	<.001	<.001	3	6
LSCC	NFX1 →	+0.500	+0.312	<.001	<.001	3	6
LSCC	SMU1 →	+0.426	+0.207	<.001	<.001	3	5
UCEC	DCTN3 →	+0.559	+0.206	.002	.005	3	5
UCEC	NDUFB6 →	+0.521	+0.219	.009	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,675 associations by consensus.

BAG1 vs GBA2 — LSCC

Explore this scatter interactively →