BAG1

Across TCGA patient cohorts, BAG1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG1-associated genes across cancer lineages are beta-Catenin, Rb_pS807_S811, and ATM. Each is linked with BAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG1-to-partner and partner-to-BAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, beta-Catenin grouped by BAG1-low versus BAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG1→partner) and Y-score (partner→BAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	beta-Catenin →	+0.605	+3.000	.038	.037	3	1
UCEC	Rb_pS807_S811 →	-0.498	-3.000	.033	.037	2	1
UCEC	ATM →	-0.974	-3.000	<.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

beta-Catenin by BAG1 expression — UCEC

Explore this box plot interactively →