BACH2

Across TCGA cell cohorts, BACH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,417 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BACH2-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, Regulation of post-translational protein modification, and Regulation of DNA repair. Each is linked with BACH2 in more than 9 cancer types. Because this analysis shows association rather than direction, both BACH2-to-partner and partner-to-BACH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by BACH2-low versus BACH2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BACH2→partner) and Y-score (partner→BACH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Termination of RNA polymerase II transcription →	+0.140	+0.927	<.001	.002	3	10
OVARY	Regulation of post-translational protein modification →	+0.053	+0.457	<.001	<.001	3	10
LARGE_INTESTINE	Regulation of DNA repair →	+0.037	+0.515	.002	.007	3	10
OVARY	Negative regulation of macroautophagy →	+0.071	+0.503	<.001	.002	3	10
OVARY	Regulation of mRNA stability →	+0.042	+0.561	.002	.001	3	10
OVARY	Protein modification by small protein removal →	+0.046	+0.452	<.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,417 associations by consensus.

Termination of RNA polymerase II transcription by BACH2 expression — STOMACH

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