BACH2

Across TCGA cell cohorts, BACH2 mutation is significantly associated with the RNA expression of many other genes, with 1,514 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BACH2-associated genes across cancer lineages are MASTL, OPN4, and HAUS2. Each is linked with BACH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACH2-to-partner and partner-to-BACH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MASTL grouped by BACH2-low versus BACH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACH2→partner) and Y-score (partner→BACH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MASTL →	+0.573	+1.936	.002	.005	3	2
LARGE_INTESTINE	OPN4 →	+0.007	+1.967	.004	.004	3	2
LARGE_INTESTINE	HAUS2 →	+0.560	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	EIF5AL1 →	+0.505	+2.364	.006	<.001	3	2
LARGE_INTESTINE	TIPIN →	+0.520	+2.364	.002	<.001	3	2
LARGE_INTESTINE	SEPHS1 →	+0.603	+2.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,514 associations by consensus.

MASTL by BACH2 expression — LARGE_INTESTINE

Explore this box plot interactively →