BACE2

Across TCGA patient cohorts, BACE2 mutation is significantly associated with the RNA expression of many other genes, with 3,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BACE2-associated genes across cancer lineages are LINC02032, TUBGCP5, and CENPU. Each is linked with BACE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BACE2-to-partner and partner-to-BACE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02032 grouped by BACE2-low versus BACE2-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE2→partner) and Y-score (partner→BACE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	LINC02032 →	+0.184	+5.662	<.001	.002	3	3
UCEC	TUBGCP5 →	+0.276	+1.254	.008	.008	3	3
COAD	CENPU →	+0.885	+3.807	<.001	<.001	3	3
UCEC	HAUS1 →	+0.454	+2.191	<.001	.001	3	3
UCEC	MTMR10 →	+0.304	+1.420	.002	.002	3	3
COAD	TIMM21 →	+0.570	+3.348	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,227 associations by consensus.

LINC02032 by BACE2 expression — ACC

Explore this box plot interactively →