BACE2

Across TCGA cell cohorts, BACE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,603 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BACE2-associated GO terms across cancer lineages are Heme transport, Viral protein processing, and Striated muscle contraction. Each is linked with BACE2 in more than 9 cancer types. Because this analysis shows association rather than direction, both BACE2-to-partner and partner-to-BACE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heme transport grouped by BACE2-low versus BACE2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE2→partner) and Y-score (partner→BACE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Heme transport →	-0.169	-2.244	.004	.003	3	10
CNS	Viral protein processing →	+0.117	+2.355	<.001	<.001	3	9
SOFT_TISSUE	Striated muscle contraction →	+0.073	+2.173	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Amyloid-beta metabolic process →	+0.125	+2.710	.005	<.001	2	10
UPPER_AERODIGESTIVE_TRACT	Regulation of leukocyte apoptotic process →	+0.080	+1.158	.001	.006	3	9
SOFT_TISSUE	Positive regulation of CD8-positive, alpha-beta T cell proliferation →	+0.219	+2.244	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,603 associations by consensus.

Heme transport by BACE2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →