BACE2

Across TCGA cell cohorts, BACE2 mutation is significantly associated with the RNA expression of many other genes, with 931 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BACE2-associated genes across cancer lineages are ASB17, C12orf40, and OR2H1. Each is linked with BACE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACE2-to-partner and partner-to-BACE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by BACE2-low versus BACE2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE2→partner) and Y-score (partner→BACE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
BLOOD_Leukemia	ACTRT2 →	+0.064	+4.922	.001	.009	3	1
BLOOD_Leukemia	MC2R →	+0.006	+5.969	<.001	.001	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 931 associations by consensus.

ASB17 by BACE2 expression — OVARY

Explore this box plot interactively →