Across TCGA patient cohorts, BACE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,688 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BACE1-associated proteins across cancer lineages are MAP1B, COL1A1, and DPYSL3. Each is linked with BACE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both BACE1-to-partner and partner-to-BACE1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE1→partner) and Y-score (partner→BACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+0.773	+0.422	<.001	<.001	3	7
CCRCC	COL1A1 →	+0.675	+0.314	<.001	.001	3	6
BRCA	DPYSL3 →	+0.684	+0.601	<.001	<.001	3	6
OV	SERPINF1 →	+0.651	+0.774	.001	.006	3	6
CCRCC	PDLIM4 →	+0.614	+0.297	.001	.001	3	6
GBM	DNM1 →	+0.767	+0.458	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,688 associations by consensus.

Exploration

BACE1 survival (RNA) · tumor vs normal (RNA) · all BACE1 data types