Across TCGA patient cohorts, BACE1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,177 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BACE1-associated genes across cancer lineages are CUX2, GNMT, and GUCA1C. Each is linked with BACE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACE1-to-partner and partner-to-BACE1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE1→partner) and Y-score (partner→BACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CUX2 →	+0.757	+0.499	<.001	<.001	3	2
PDAC	GNMT →	+1.500	+1.069	.003	.002	3	2
PDAC	GUCA1C →	+1.602	+1.201	.006	.001	3	2
GBM	CDH22 →	+1.209	+0.541	<.001	<.001	3	2
PDAC	NPHS1 →	+0.747	+1.004	<.001	.001	3	2
PDAC	TRPV6 →	+1.245	+1.130	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,177 associations by consensus.

Exploration

BACE1 survival (RNA) · tumor vs normal (RNA) · all BACE1 data types