Across TCGA patient cohorts, BACE1 mutation is significantly associated with the RNA expression of many other genes, with 4,498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BACE1-associated genes across cancer lineages are YBX1P9, RNU6-13P, and ANKRD49P3. Each is linked with BACE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BACE1-to-partner and partner-to-BACE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE1→partner) and Y-score (partner→BACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	YBX1P9 →	+0.084	+5.010	<.001	.009	3	3
READ	RNU6-13P →	+0.631	+5.039	<.001	.008	3	2
READ	ANKRD49P3 →	+0.123	+5.039	.005	.008	3	2
SKCM	RPS17P8 →	+0.153	+4.563	.001	.004	3	2
UCEC	RPS29P32 →	+0.405	+2.521	<.001	<.001	3	2
CESC	RNU6-912P →	+0.442	+5.010	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,498 associations by consensus.

Exploration

BACE1 survival (RNA) · tumor vs normal (RNA) · all BACE1 data types