Across TCGA patient cohorts, BACE1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BACE1-associated genes across cancer lineages are Notch1, PCNA, and Bak. Each is linked with BACE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACE1-to-partner and partner-to-BACE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE1→partner) and Y-score (partner→BACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.141	+2.472	.005	.010	3	2
UCEC	PCNA →	+0.167	+1.700	.032	.042	3	2
UCEC	Bak →	+0.210	+2.321	.019	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.440	+2.479	.039	.010	3	2
UCEC	14-3-3_beta →	-0.135	-3.880	<.001	<.001	3	1
UCEC	eEF2 →	+0.439	+2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

BACE1 survival (RNA) · tumor vs normal (RNA) · all BACE1 data types