Across TCGA cell cohorts, BACE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,044 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BACE1-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Golgi vesicle transport, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with BACE1 in more than 15 cancer types. Because this analysis shows association rather than direction, both BACE1-to-partner and partner-to-BACE1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE1→partner) and Y-score (partner→BACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.075	+1.588	<.001	<.001	3	16
BONE	Golgi vesicle transport →	+0.064	+1.893	.004	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.090	+1.104	<.001	<.001	3	14
STOMACH	Negative regulation of myoblast fusion →	+0.135	+1.912	.003	.001	3	14
PANCREAS	Establishment of protein localization to membrane →	+0.048	+0.637	<.001	.005	3	13
STOMACH	Protein polyubiquitination →	+0.064	+1.987	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,044 associations by consensus.

Exploration

BACE1 survival (RNA) · tumor vs normal (RNA) · all BACE1 data types