Across TCGA cell cohorts, BACE1 mutation is significantly associated with the drug of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BACE1-associated genes across cancer lineages are Vinblastine, Lestaurtinib, and IAP_5620. Each is linked with BACE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACE1-to-partner and partner-to-BACE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACE1→partner) and Y-score (partner→BACE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Vinblastine →	+0.910	+2.655	.035	.044	3	1
LARGE_INTESTINE	Lestaurtinib →	+0.628	+2.710	.010	.043	3	1
LARGE_INTESTINE	IAP_5620 →	+0.349	+2.871	.046	.021	3	1
LARGE_INTESTINE	150412 →	+0.369	+3.000	.020	.017	3	1
LARGE_INTESTINE	630600 →	+0.598	+2.871	.043	.021	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.597	+2.868	.010	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

BACE1 survival (RNA) · tumor vs normal (RNA) · all BACE1 data types