BABAM2

Across TCGA patient cohorts, BABAM2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BABAM2-associated genes across cancer lineages are ATM, 4E-BP1, and p38-MAPK_pT180_Y182. Each is linked with BABAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BABAM2-to-partner and partner-to-BABAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BABAM2-low versus BABAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BABAM2→partner) and Y-score (partner→BABAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.636	-2.321	<.001	.006	3	3
UCEC	4E-BP1 →	+0.384	+3.489	<.001	.002	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.515	-1.794	.005	.027	3	2
SKCM	Caspase-8 →	-0.181	-3.000	.029	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.174	-2.321	.012	.034	3	1
UCEC	JNK2 →	+0.250	+2.594	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by BABAM2 expression — UCEC

Explore this box plot interactively →