B4GALT3

Across TCGA pan-cancer cohorts, B4GALT3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated B4GALT3 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher B4GALT3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated B4GALT3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UVM show a favorable association.

LIHC, ACC, and KIRP are the cancer types where B4GALT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.598	0.779	<.001	92	view →
ACC	DFS	Median	All	0.174	0.692	<.001	83	view →
KIRP	DFS	Median	III,IV	0.436	0.739	.006	65	view →
CESC	DFS	Median	III,IV	0.425	0.799	<.001	48	view →
BRCA	DFS	Quartile	All	0.869	0.937	.002	44	view →
KIRC	DFS	Tertile	III,IV	0.599	0.845	.001	41	view →
HNSC	OS	Tertile	All	0.252	0.490	.008	34	view →
LUSC	DFS	Quartile	III,IV	0.298	0.711	<.001	28	view →
UCEC	DFS	Tertile	All	0.590	0.719	.003	22	view →
SARC	OS	Median	All	0.630	0.821	.003	19	view →
KICH	OS	Quartile	II,III,IV	0.397	0.895	.008	17	view →
ESCA	DFS	Median	III,IV	0.331	0.544	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

B4GALT3–LIHC (OS)

Open the LIHC breakdown →