B4GALNT1

Across TCGA pan-cancer cohorts, B4GALNT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of B4GALNT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where B4GALNT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types B4GALNT1 is over-expressed in tumor, although a few such as PRAD and READ show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where B4GALNT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in B4GALNT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+1.941	<.001	12	view →
LUAD	Male	II,III,IV	+1.392	<.001	9	view →
LIHC	Male	II,III,IV	+1.473	<.001	8	view →
KIRP	All	II,III,IV	+0.813	<.001	8	view →
LUSC	Male	II,III,IV	+2.207	<.001	7	view →
KIRC	All	All	+1.059	<.001	7	view →
BRCA	Female	II,III,IV	+0.574	<.001	6	view →
KICH	All	II,III,IV	+0.565	.017	4	view →
CHOL	All	All	+0.943	<.001	3	view →
PRAD	All	All	−0.540	<.001	2	view →
READ	Female	All	−0.820	.017	1	view →
COAD	Female	II,III,IV	−0.265	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

B4GALNT1–HNSC

Open the HNSC breakdown →