B3GNT8

Across TCGA patient cohorts, B3GNT8 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible B3GNT8-associated genes across cancer lineages are EGFR_pY1068, JNK2, and N-Ras. Each is linked with B3GNT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both B3GNT8-to-partner and partner-to-B3GNT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by B3GNT8-low versus B3GNT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (B3GNT8→partner) and Y-score (partner→B3GNT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.326	-3.000	.024	.037	3	1
UCEC	JNK2 →	+0.296	+3.000	.010	.037	3	1
UCEC	N-Ras →	-0.136	-2.986	.047	.037	3	1
UCEC	Rictor_pT1135 →	-0.126	-3.000	.033	.037	3	1
UCEC	STAT5a →	+0.511	+3.000	.027	.037	3	1
UCEC	ATM →	-0.725	-3.000	.005	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by B3GNT8 expression — UCEC

Explore this box plot interactively →