B3GAT3

Across TCGA pan-cancer cohorts, B3GAT3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of B3GAT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where B3GAT3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types B3GAT3 is over-expressed in tumor.

HNSC, LSCC, and CCRCC are the cancer types where B3GAT3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in B3GAT3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.458	<.001	8	view →
LSCC	Male	III,IV	+0.399	<.001	7	view →
CCRCC	All	II,III,IV	+0.170	.006	7	view →
LUAD	Female	All	+0.282	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

B3GAT3–HNSC

Open the HNSC breakdown →