B3GALT6

Across TCGA pan-cancer cohorts, B3GALT6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated B3GALT6 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher B3GALT6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated B3GALT6 expression acts as an unfavorable survival marker, although some lineages such as THYM and ESCA show a favorable association.

ACC, BLCA, and LIHC are the cancer types where B3GALT6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.206	0.684	<.001	123	view →
BLCA	OS	Tertile	All	0.588	0.788	.016	51	view →
LIHC	DFS	Tertile	All	0.343	0.520	<.001	45	view →
COAD	DFS	Tertile	II,III,IV	0.657	0.897	<.001	36	view →
THYM	DFS	Median	All	1.000	0.726	.001	36	view →
LGG	DFS	Median	All	0.666	0.810	<.001	27	view →
ESCA	DFS	Tertile	All	1.000	0.244	<.001	27	view →
DLBC	DFS	Median	II,III,IV	0.477	1.000	.005	25	view →
CHOL	DFS	Median	All	0.635	0.186	.008	24	view →
SCLC	OS	Tertile	All	0.476	0.143	<.001	23	view →
MESO	DFS	Tertile	III,IV	0.743	0.165	.006	18	view →
SARC	OS	Quartile	All	0.614	0.835	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

B3GALT6–ACC (DFS)

Open the ACC breakdown →