Across TCGA pan-cancer cohorts, B3GALT5 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of B3GALT5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where B3GALT5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types B3GALT5 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, PDAC, and CCRCC are the cancer types where B3GALT5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in B3GALT5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.601	<.001	11	view →
PDAC	All	All	+0.491	<.001	5	view →
CCRCC	Male	II,III,IV	+0.553	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: B3GALT5 RNA expression & survival · all B3GALT5 data types