B3GALT2

Across TCGA pan-cancer cohorts, B3GALT2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated B3GALT2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher B3GALT2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated B3GALT2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

UVM, LUAD, and KIRC are the cancer types where B3GALT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.285	0.707	<.001	133	view →
LUAD	OS	Median	All	0.745	0.620	<.001	79	view →
KIRC	DFS	Median	All	0.729	0.557	.001	78	view →
UCS	DFS	Tertile	II,III,IV	0.576	0.116	.002	72	view →
HNSC	DFS	Tertile	All	0.749	0.605	<.001	69	view →
BLCA	OS	Tertile	All	0.312	0.567	.002	69	view →
BRCA	OS	Median	IV	0.962	0.455	.001	68	view →
PAAD	OS	Quartile	All	0.571	0.275	.001	54	view →
SKCM	DFS	Quartile	II,III,IV	0.389	0.174	.002	51	view →
LGG	DFS	Tertile	All	0.790	0.617	<.001	44	view →
SCLC	DFS	Quartile	III,IV	0.825	0.373	.004	29	view →
LIHC	DFS	Quartile	All	0.518	0.237	<.001	29	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

B3GALT2–UVM (DFS)

Open the UVM breakdown →