AZIN1

Across TCGA patient cohorts, AZIN1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AZIN1-associated genes across cancer lineages are INPP4B, ATM, and EGFR_pY1068. Each is linked with AZIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AZIN1-to-partner and partner-to-AZIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by AZIN1-low versus AZIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AZIN1→partner) and Y-score (partner→AZIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.245	-1.906	.028	.015	3	2
UCEC	ATM →	-0.430	-1.440	.006	.024	3	2
UCEC	EGFR_pY1068 →	-0.212	-1.440	.014	.024	3	1
UCEC	eIF4E →	+0.152	+3.335	.038	.005	3	1
UCEC	eIF4G →	+0.235	+3.169	.029	.018	3	1
UCEC	A-Raf_pS299 →	-0.107	-2.321	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

INPP4B by AZIN1 expression — UCEC

Explore this box plot interactively →