AZI2

Across TCGA patient cohorts, AZI2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AZI2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and MSH2. Each is linked with AZI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AZI2-to-partner and partner-to-AZI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AZI2-low versus AZI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AZI2→partner) and Y-score (partner→AZI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.756	+3.019	.008	.019	3	2
UCEC	EGFR_pY1068 →	-0.264	-2.459	.029	.020	3	1
UCEC	MSH2 →	-0.323	-2.973	.003	.035	3	1
UCEC	p62 Lck ligand →	+0.452	+3.584	.004	.002	3	1
UCEC	PDK1_pS241 →	+0.198	+2.833	.016	.034	3	1
UCEC	Annexin-1 →	+0.565	+2.459	.026	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-7-cleavedD198 by AZI2 expression — UCEC

Explore this box plot interactively →