AZGP1

Across TCGA patient cohorts, AZGP1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AZGP1-associated genes across cancer lineages are Tuberin_pT1462, 14-3-3_beta, and EGFR_pY1068. Each is linked with AZGP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AZGP1-to-partner and partner-to-AZGP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by AZGP1-low versus AZGP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AZGP1→partner) and Y-score (partner→AZGP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.308	+1.594	.002	.042	3	2
UCEC	14-3-3_beta →	-0.138	-3.295	.001	.009	3	1
UCEC	EGFR_pY1068 →	-0.318	-3.459	.003	.005	3	1
UCEC	A-Raf_pS299 →	-0.199	-3.321	<.001	.010	3	1
UCEC	FoxM1 →	+0.334	+2.115	.003	.019	3	1
UCEC	Gab2 →	+0.467	+2.115	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Tuberin_pT1462 by AZGP1 expression — UCEC

Explore this box plot interactively →