AXL

Across TCGA patient cohorts, AXL protein abundance is significantly associated with the RNA expression of many other genes, with 9,768 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AXL-associated genes across cancer lineages are SIGLEC9, C1QC, and LRRC25. Each is linked with AXL in more than 4 cancer types. Because this analysis shows association rather than direction, both AXL-to-partner and partner-to-AXL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AXL versus SIGLEC9 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXL→partner) and Y-score (partner→AXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIGLEC9 →	+0.875	+0.457	.001	.001	3	5
LUAD	C1QC →	+0.797	+0.255	<.001	<.001	3	5
GBM	LRRC25 →	+0.839	+0.431	.001	.002	3	5
LSCC	GREM1 →	+1.381	+0.419	<.001	<.001	3	4
OV	MLKL →	+0.683	+0.516	.005	.003	3	4
GBM	ADGRE4P →	+0.718	+0.397	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,768 associations by consensus.

AXL vs SIGLEC9 — GBM

Explore this scatter interactively →