AXL

Across TCGA patient cohorts, AXL mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AXL-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and 4E-BP1. Each is linked with AXL in more than 3 cancer types. Because this analysis shows association rather than direction, both AXL-to-partner and partner-to-AXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AXL-low versus AXL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXL→partner) and Y-score (partner→AXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.468	+1.584	.004	.015	3	4
UCEC	eIF4E →	+0.139	+1.447	.018	.002	3	3
UCEC	4E-BP1 →	+0.182	+1.392	.017	.021	3	3
STAD	LKB1 →	+0.132	+3.000	.017	.036	1	4
COAD	RAD51 →	+0.159	+2.178	.031	.035	3	2
COAD	TIGAR →	+0.471	+3.330	.011	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by AXL expression — UCEC

Explore this box plot interactively →