AXL

Across TCGA cell cohorts, AXL RNA expression is significantly associated with the go_rna of many other GO terms, with 6,516 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AXL-associated GO terms across cancer lineages are Regulation of smooth muscle cell-matrix adhesion, Regulation of plasminogen activation, and Regulation of cell-substrate adhesion. Each is linked with AXL in more than 16 cancer types. Because this analysis shows association rather than direction, both AXL-to-partner and partner-to-AXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smooth muscle cell-matrix adhesion grouped by AXL-low versus AXL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AXL→partner) and Y-score (partner→AXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of smooth muscle cell-matrix adhesion →	+1.544	+5.435	.001	<.001	3	17
BONE	Regulation of plasminogen activation →	+0.274	+5.354	<.001	<.001	3	16
BONE	Regulation of cell-substrate adhesion →	+0.125	+3.487	<.001	<.001	3	16
BONE	Dentinogenesis →	+1.846	+4.211	<.001	<.001	3	16
LIVER	Positive regulation of establishment of T cell polarity →	+0.240	+4.156	<.001	<.001	3	16
BONE	Positive regulation of cell-substrate adhesion →	+0.121	+3.783	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,516 associations by consensus.

Regulation of smooth muscle cell-matrix adhesion by AXL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →