AXL

Across TCGA cell cohorts, AXL mutation is significantly associated with the RNA expression of many other genes, with 1,861 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AXL-associated genes across cancer lineages are GGTLC1, SCGB1C1, and OPN1MW3. Each is linked with AXL in more than 1 cancer types. Because this analysis shows association rather than direction, both AXL-to-partner and partner-to-AXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGTLC1 grouped by AXL-low versus AXL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXL→partner) and Y-score (partner→AXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GGTLC1 →	+0.089	+3.345	<.001	.007	3	2
PANCREAS	SCGB1C1 →	+0.060	+5.614	<.001	.002	3	1
PANCREAS	OPN1MW3 →	+0.013	+5.614	<.001	.002	3	1
PANCREAS	FAM240A →	+0.013	+5.614	<.001	.002	3	1
SKIN	CACNA1F →	+0.085	+3.823	.001	.006	3	1
SKIN	C1QC →	+0.022	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,861 associations by consensus.

GGTLC1 by AXL expression — SKIN

Explore this box plot interactively →