AXIN1

Across TCGA pan-cancer cohorts, AXIN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AXIN1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AXIN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated AXIN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where AXIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.806	0.429	<.001	39	view →
LSCC	DFS	Quartile	All	0.938	0.563	.010	7	view →
LUAD	DFS	Median	III,IV	0.265	0.922	.038	3	view →
PDAC	DFS	Median	II,III,IV	0.285	0.749	.012	3	view →
UCEC	DFS	Median	All	0.959	0.848	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AXIN1–HNSC (OS)

Open the HNSC breakdown →