AXIN1

Across TCGA patient cohorts, AXIN1 mutation is significantly associated with the RNA expression of many other genes, with 2,642 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AXIN1-associated genes across cancer lineages are BCCIP, KNL1, and TAF9. Each is linked with AXIN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AXIN1-to-partner and partner-to-AXIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCCIP grouped by AXIN1-low versus AXIN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXIN1→partner) and Y-score (partner→AXIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BCCIP →	+0.479	+2.267	.003	.001	3	4
UCEC	KNL1 →	+0.543	+2.423	.001	.001	3	4
LIHC	TAF9 →	+0.648	+3.914	<.001	<.001	3	3
UCEC	ZFYVE19 →	+0.427	+4.108	<.001	<.001	3	3
SKCM	HINT1 →	+0.363	+2.835	.003	.001	3	3
SKCM	VDAC1 →	+0.406	+2.267	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,642 associations by consensus.

BCCIP by AXIN1 expression — SKCM

Explore this box plot interactively →