AXIN1

Across TCGA cell cohorts, AXIN1 mutation is significantly associated with the RNA expression of many other genes, with 375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AXIN1-associated genes across cancer lineages are MPDU1, CBY1, and IL7. Each is linked with AXIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AXIN1-to-partner and partner-to-AXIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPDU1 grouped by AXIN1-low versus AXIN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXIN1→partner) and Y-score (partner→AXIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MPDU1 →	+0.544	+2.588	.003	.004	3	2
LARGE_INTESTINE	CBY1 →	+0.595	+3.330	.001	.002	3	1
LARGE_INTESTINE	IL7 →	+0.943	+2.588	<.001	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.281	+2.837	<.001	.001	3	1
LARGE_INTESTINE	ACBD5 →	+0.822	+3.628	.001	<.001	3	1
LARGE_INTESTINE	SHOC2 →	+0.440	+2.502	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 375 associations by consensus.

MPDU1 by AXIN1 expression — LARGE_INTESTINE

Explore this box plot interactively →