AXDND1

Across TCGA patient cohorts, AXDND1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AXDND1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and Ku80. Each is linked with AXDND1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AXDND1-to-partner and partner-to-AXDND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by AXDND1-low versus AXDND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXDND1→partner) and Y-score (partner→AXDND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.159	-1.415	.036	.043	3	3
UCEC	INPP4B →	-0.241	-2.502	.013	.001	3	3
UCEC	Ku80 →	+0.244	+1.768	<.001	<.001	3	3
COAD	Cyclin-E2 →	+0.337	+3.025	.005	.018	3	3
COAD	ASNS →	+0.961	+3.008	<.001	.019	3	2
UCEC	JNK2 →	+0.177	+1.999	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

EGFR_pY1068 by AXDND1 expression — UCEC

Explore this box plot interactively →