AXDND1

Across TCGA cell cohorts, AXDND1 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AXDND1-associated genes across cancer lineages are RELCH, BTBD16, and HS3ST3A1. Each is linked with AXDND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AXDND1-to-partner and partner-to-AXDND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RELCH grouped by AXDND1-low versus AXDND1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXDND1→partner) and Y-score (partner→AXDND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RELCH →	+0.562	+3.212	<.001	.006	3	2
BLOOD_Leukemia	BTBD16 →	+0.075	+3.181	<.001	.001	3	1
BLOOD_Leukemia	HS3ST3A1 →	+1.393	+3.247	<.001	.009	3	1
BLOOD_Leukemia	AQP12B →	+0.176	+2.604	<.001	.006	3	1
BLOOD_Leukemia	ERVFRD-1 →	+0.687	+3.449	<.001	.003	3	1
BLOOD_Leukemia	CHAT →	+0.811	+3.015	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

RELCH by AXDND1 expression — SKIN

Explore this box plot interactively →