AVPR2

Across TCGA patient cohorts, AVPR2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVPR2-associated genes across cancer lineages are eEF2, p53, and Rictor_pT1135. Each is linked with AVPR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AVPR2-to-partner and partner-to-AVPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AVPR2-low versus AVPR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVPR2→partner) and Y-score (partner→AVPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.324	+1.662	.010	.011	3	2
UCEC	p53 →	-0.354	-3.321	.009	.009	3	2
UCEC	Rictor_pT1135 →	-0.106	-2.000	.003	.009	3	2
UCEC	TFRC →	+0.748	+3.807	<.001	<.001	3	2
UCEC	ATM →	-0.427	-2.700	.007	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.632	+2.926	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

eEF2 by AVPR2 expression — UCEC

Explore this box plot interactively →