AVL9

Across TCGA patient cohorts, AVL9 mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVL9-associated genes across cancer lineages are IGLVVI-25-1, ST6GALNAC2P1, and RNU6-461P. Each is linked with AVL9 in more than 2 cancer types. Because this analysis shows association rather than direction, both AVL9-to-partner and partner-to-AVL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLVVI-25-1 grouped by AVL9-low versus AVL9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVL9→partner) and Y-score (partner→AVL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGLVVI-25-1 →	+0.121	+4.711	<.001	.004	3	3
BRCA	ST6GALNAC2P1 →	+0.036	+4.786	.007	.004	3	3
LGG	RNU6-461P →	+0.303	+7.977	<.001	.007	3	2
LGG	RNU6-715P →	+0.313	+7.977	<.001	.007	3	2
UCEC	TRAJ12 →	+0.738	+2.581	<.001	<.001	3	2
UCEC	IGHD2-2 →	+1.388	+2.387	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

IGLVVI-25-1 by AVL9 expression — BRCA

Explore this box plot interactively →