AVL9

Across TCGA patient cohorts, AVL9 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVL9-associated genes across cancer lineages are Bid, A-Raf_pS299, and ERCC1. Each is linked with AVL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both AVL9-to-partner and partner-to-AVL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bid grouped by AVL9-low versus AVL9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVL9→partner) and Y-score (partner→AVL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bid →	-0.119	-2.459	.040	.020	3	2
UCEC	A-Raf_pS299 →	-0.128	-3.000	.026	.036	3	1
UCEC	ERCC1 →	-0.165	-3.169	.047	.019	3	1
UCEC	MEK1 →	+0.495	+3.584	.005	.002	3	1
UCEC	Notch1 →	+0.230	+3.179	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.435	+3.331	.005	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Bid by AVL9 expression — UCEC

Explore this box plot interactively →