AVL9

Across TCGA cell cohorts, AVL9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,269 significant associations in total. CNS shows the largest number of these associations.

The most reproducible AVL9-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Receptor recycling, and Meiotic mismatch repair. Each is linked with AVL9 in more than 11 cancer types. Because this analysis shows association rather than direction, both AVL9-to-partner and partner-to-AVL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by AVL9-low versus AVL9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AVL9→partner) and Y-score (partner→AVL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.124	+0.566	.001	.006	3	12
KIDNEY	Receptor recycling →	+0.067	+0.849	<.001	.001	3	11
BLOOD_Lymphoma	Meiotic mismatch repair →	+0.127	+0.890	<.001	.001	3	10
SKIN	Golgi vesicle transport →	+0.046	+0.613	.001	<.001	3	10
LUNG_SCLC	Peptidyl-threonine phosphorylation →	+0.092	+0.558	.001	<.001	3	9
LUNG_SCLC	Peptidyl-threonine modification →	+0.092	+0.558	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,269 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by AVL9 expression — BONE

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