AVIL

Across TCGA patient cohorts, AVIL mutation is significantly associated with the RNA expression of many other genes, with 2,837 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVIL-associated genes across cancer lineages are PSMD9, PIMREG, and MPDU1. Each is linked with AVIL in more than 2 cancer types. Because this analysis shows association rather than direction, both AVIL-to-partner and partner-to-AVIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by AVIL-low versus AVIL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVIL→partner) and Y-score (partner→AVIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD9 →	+0.364	+1.864	<.001	.004	3	3
UCEC	PIMREG →	+0.668	+2.557	<.001	<.001	3	3
UCEC	MPDU1 →	+0.316	+2.263	.005	.005	3	3
UCEC	REEP5 →	+0.314	+3.032	<.001	<.001	3	3
UCEC	SRPK3 →	-0.553	-1.847	.009	.008	3	3
UCEC	OXA1L →	+0.268	+2.544	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,837 associations by consensus.

PSMD9 by AVIL expression — UCEC

Explore this box plot interactively →