AVIL

Across TCGA patient cohorts, AVIL mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVIL-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and Annexin-1. Each is linked with AVIL in more than 3 cancer types. Because this analysis shows association rather than direction, both AVIL-to-partner and partner-to-AVIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AVIL-low versus AVIL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVIL→partner) and Y-score (partner→AVIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.761	+2.267	<.001	<.001	3	4
UCEC	MSH2 →	-0.215	-1.558	.004	.032	3	2
UCEC	Annexin-1 →	+0.717	+2.999	<.001	<.001	3	2
UCEC	BRD4 →	+0.277	+2.233	.002	.005	3	2
UCEC	Cyclin-B1 →	+0.654	+2.263	<.001	<.001	3	2
STAD	HER3_pY1289 →	+0.099	+2.828	.046	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by AVIL expression — UCEC

Explore this box plot interactively →