AVIL

Across TCGA cell cohorts, AVIL mutation is significantly associated with the RNA expression of many other genes, with 473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AVIL-associated genes across cancer lineages are IL21, OR4C45, and CBY1. Each is linked with AVIL in more than 1 cancer types. Because this analysis shows association rather than direction, both AVIL-to-partner and partner-to-AVIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by AVIL-low versus AVIL-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVIL→partner) and Y-score (partner→AVIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL21 →	+0.005	+4.781	<.001	.003	3	1
BREAST	OR4C45 →	+0.017	+4.781	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.855	+3.160	<.001	.006	3	1
LARGE_INTESTINE	CTSZ →	-1.749	-3.169	<.001	.009	3	1
LARGE_INTESTINE	NISCH →	+0.731	+3.067	.003	.009	3	1
LARGE_INTESTINE	CCP110 →	+0.737	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 473 associations by consensus.

IL21 by AVIL expression — BREAST

Explore this box plot interactively →