AVEN

Across TCGA patient cohorts, AVEN mutation is significantly associated with the RNA expression of many other genes, with 735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVEN-associated genes across cancer lineages are LINC02559, LINC01227, and SNRPCP20. Each is linked with AVEN in more than 1 cancer types. Because this analysis shows association rather than direction, both AVEN-to-partner and partner-to-AVEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by AVEN-low versus AVEN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVEN→partner) and Y-score (partner→AVEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.780	+6.342	<.001	.001	3	2
UCEC	LINC01227 →	+0.064	+2.192	<.001	.001	3	2
UCEC	SNRPCP20 →	+0.207	+2.174	<.001	.005	3	2
SKCM	RNU6-937P →	+0.280	+3.018	.007	.009	3	2
UCEC	CLEC18B →	+0.445	+3.537	.008	.002	3	2
LUSC	KRTAP12-6P →	+0.232	+4.882	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 735 associations by consensus.

LINC02559 by AVEN expression — CESC

Explore this box plot interactively →