AVEN

Across TCGA patient cohorts, AVEN mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AVEN-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with AVEN in more than 1 cancer types. Because this analysis shows association rather than direction, both AVEN-to-partner and partner-to-AVEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AVEN-low versus AVEN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVEN→partner) and Y-score (partner→AVEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.455	+3.169	.006	.019	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.584	.015	.011	3	1
UCEC	A-Raf_pS299 →	-0.145	-2.999	.009	.035	3	1
UCEC	INPP4B →	-0.359	-2.999	.017	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.207	-3.321	.008	.009	3	1
UCEC	JNK2 →	+0.299	+2.584	.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eEF2 by AVEN expression — UCEC

Explore this box plot interactively →