AVEN

Across TCGA cell cohorts, AVEN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,855 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AVEN-associated GO terms across cancer lineages are Regulation of cell cycle checkpoint, Regulation of spindle checkpoint, and Regulation of transforming growth factor beta receptor signaling pathway. Each is linked with AVEN in more than 8 cancer types. Because this analysis shows association rather than direction, both AVEN-to-partner and partner-to-AVEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle checkpoint grouped by AVEN-low versus AVEN-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AVEN→partner) and Y-score (partner→AVEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of cell cycle checkpoint →	+0.086	+1.111	<.001	<.001	3	9
CNS	Regulation of spindle checkpoint →	+0.105	+0.908	<.001	<.001	3	9
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.080	+1.152	<.001	<.001	3	9
BONE	Regulation of cellular response to transforming growth factor beta stimulus →	+0.082	+1.182	<.001	<.001	3	9
CNS	Endoplasmic reticulum localization →	+0.154	+0.941	<.001	<.001	3	8
BREAST	Positive regulation of cytoskeleton organization →	+0.085	+1.075	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,855 associations by consensus.

Regulation of cell cycle checkpoint by AVEN expression — CNS

Explore this box plot interactively →