AVEN

Across TCGA cell cohorts, AVEN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AVEN-associated genes across cancer lineages are CCL19, KIR2DS4, and RGS21. Each is linked with AVEN in more than 1 cancer types. Because this analysis shows association rather than direction, both AVEN-to-partner and partner-to-AVEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL19 grouped by AVEN-low versus AVEN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVEN→partner) and Y-score (partner→AVEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCL19 →	+0.098	+4.930	<.001	.001	3	1
LARGE_INTESTINE	KIR2DS4 →	+0.012	+4.930	<.001	.001	3	1
LARGE_INTESTINE	RGS21 →	+0.024	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1
BLOOD_Leukemia	SPATA19 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR6B3 →	+0.022	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CCL19 by AVEN expression — LARGE_INTESTINE

Explore this box plot interactively →