AUTS2

Across TCGA pan-cancer cohorts, AUTS2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AUTS2 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AUTS2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AUTS2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where AUTS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.916	0.429	.011	20	view →
LUAD	DFS	Median	All	0.757	0.466	.010	18	view →
HNSC	OS	Median	All	0.811	0.916	.020	14	view →
PDAC	DFS	Median	III,IV	0.359	0.792	.009	10	view →
LSCC	OS	Median	II,III,IV	0.878	0.626	.026	3	view →
GBM	DFS	Quartile	All	0.445	0.285	.036	2	view →
CCRCC	DFS	Tertile	All	1.000	0.524	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AUTS2–UCEC (DFS)

Open the UCEC breakdown →